Subscribe to our RSS feed

Popular News Stories

  • Fuck poz guys!
  • Tom Hanks in Philadelphia Changed my Life
  • Canadian AIDS Society’s AGM and PHA Forum in Ottawa: some scholarships for HIVers available
  • BareBackRT.com  - the interview
  • Semen goes viral – or does it?

Hep B and C

Nov29

Co-infection news - new treatments for hepatitis C

Saturday, 29 November 2014 Written by // Guest Authors - Revolving Door Categories // Hep B and C, Research, Health, Treatment, Living with HIV, Revolving Door, Guest Authors

aidsmap.com reports there’s more good news on treatment for hepatitis C. In several trials of new hepatitis C drugs involving people with hepatitis C and HIV co-infection, over 90% of HIV-positive people had no traces of hepatitis C after 12 weeks

Co-infection news  - new treatments for hepatitis C

This article previously appeared in HIVupdate, a publication of aidsmap.com 

There’s more good news on treatment for hepatitis C. In several trials of new hepatitis C drugs involving people with hepatitis C and HIV co-infection, over 90% of HIV-positive people had no traces of hepatitis C after 12 weeks of treatment. The drug regimens are made up of tablets only, often with more than one drug combined into a single tablet, and no injections of interferon are needed.

Until recently, it was thought that recommendations for treating people who have HIV and hepatitis C co-infection had to be different from those for people with hepatitis C mono-infection. This was because people with HIV co-infection tended to have a poorer response to hepatitis C treatment and separate clinical trials were needed.

But we now know that when a potent combination of two or three new hepatitis C drugs is taken, people with HIV co-infection can have results that are comparable to people who only have hepatitis C.

In the following studies, people were generally already doing well on HIV treatment, with undetectable viral loads and good CD4 counts. But most had hepatitis C genotype 1a, which until now has been considered ‘hard to treat’. And most had an inherited gene which meant that they would probably not do well on hepatitis treatment that includes interferon injections.

The first study tested two new drugs, sofosbuvir and ledipasvir, which are combined in a single tablet called Harvoni. The tablet was approved by European regulators last week. Researchers gave the treatment to 50 HIV-positive people, none of whom had taken hepatitis C treatment before. Most had a high hepatitis C viral load and a quarter had advanced liver fibrosis (but none had cirrhosis, the more serious scarring of the liver). After 12 weeks of treatment, all but one of the patients were cured of hepatitis C.

A rival drug company is offering a regimen which includes three new drugs. This regimen involves a tablet called Viekirax (which combines two new drugs, ombitasvir and paritaprevir, as well as a ritonavir booster), another new drug dasabuvir (Exviera), and the option to take these alongside the existing drug ribavirin. European regulators have given preliminary support to this combination, with a final decision expected next year.

To test this regimen, another small study recruited HIV-positive people who were mostly taking hepatitis treatment for the first time. One in five had liver cirrhosis. Whether people took the drugs for 12 or 24 weeks, over 90% had no traces of hepatitis C after the treatment was finished. A larger trial will confirm which length of treatment is best.

And another study tested the so-far unlicensed combination of two new drugs, grazoprevir and elbasvir. Treatment for people living with HIV was most successful when the combination was taken along with ribavirin – in 97% of people, hepatitis C could not be detected.

In all these studies, side-effects were not a major problem.

Finally, a study showed good outcomes for people living with HIV who had liver transplants. The transplants were all done because the person had hepatocellular carcinoma (HCC, a type of liver cancer that may occur when a person has cirrhosis). People who had a transplant did better than people who had their liver cancer treated in another way. Outcomes after a transplant were as good for people living with HIV as for people who didn’t have HIV. HIV UPdate, a publication of aidsmap.com 

Arts and Entertainment Section

Activism Section

  • Storming the cathedral

    Storming the cathedral

    Bob Leahy and the 1989 ACT Up protest that saw angry demonstrators enter St Michaels Cathedral In New York during Mass and disrupt the service - and the drama that followed, including footage of their later appearance on the Phil Donahue TV show
  • (Modern, Political, Radical) Pulp Friction

    (Modern, Political, Radical) Pulp Friction

    Another poem from guest contributor Michael Carosone who says we need more positivity, more role models, more anger and more loud voices
  • AIDS denialism in London – is it really 2015?

    AIDS denialism in London – is it really 2015?

    A report from London says it’s still alive: “39 million deaths are not enough to prevent a small group of discredited people to continue spreading lies and myths about HIV, alleging that the virus has nothing to do with AIDS, or even denying it exists"

Current Affairs Section

Events Section

Features and Interviews Section

  • Lt. Colonel Ken Pinkela's petition

    Lt. Colonel Ken Pinkela's petition

    You read his interview with Bob Leahy on PositiveLite.com. Now Lt Colonel Ken Pinkela, who seems to have been criminalized unjustly, files a petition with 72,983 signatures for a full review of his case.
  • Sean Strub and the legacy of AIDS

    Sean Strub and the legacy of AIDS

    Mark S. King interviews Sean Strub, founder of POZ Magazine and a lifelong advocate for those of us living with HIV
  • Military justice?

    Military justice?

    An extraordinary example of HIV criminalization gone awry in the States. Bob Leahy talks to Lt. Colonel Ken Pinkela, court martialed and sentenced to a jail term for allegedly exposing another officer to HIV, when no sexual contact occurred, says Pinkela.

Health Section

International Section

  • Storming the cathedral

    Storming the cathedral

    Bob Leahy and the 1989 ACT Up protest that saw angry demonstrators enter St Michaels Cathedral In New York during Mass and disrupt the service - and the drama that followed, including footage of their later appearance on the Phil Donahue TV show
  • A very winning prevention combo

    A very winning prevention combo

    Aidsmap reports that combining PrEP and ART could almost eliminate HIV infection, an east African study finds
  • How does Canada compare?

    How does Canada compare?

    Our contributor Samantha on The Link Up Project that researched the global needs and priorities of young people living with or affected by HIV and some observations on how Canada stacks up on this and other prevention initiatives.

Legal Section

Lifestyle Section

Living with HIV Section

Media Section

Opinion Pieces Section

Population Specific Section

  • Storming the cathedral

    Storming the cathedral

    Bob Leahy and the 1989 ACT Up protest that saw angry demonstrators enter St Michaels Cathedral In New York during Mass and disrupt the service - and the drama that followed, including footage of their later appearance on the Phil Donahue TV show
  • How does Canada compare?

    How does Canada compare?

    Our contributor Samantha on The Link Up Project that researched the global needs and priorities of young people living with or affected by HIV and some observations on how Canada stacks up on this and other prevention initiatives.
  • The fear of being HIV Positive

    The fear of being HIV Positive

    Gary Nelson on being HIV-negative, on how fear and anger are always n the background as well as the bonds it creates

Sex and Sexuality Section

MarketPlace